Long-term apomorphine in rats: Relationship of apomorphine-induced stereotypy to brain concentrations
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چکیده
منابع مشابه
Turmeric active substance, curcumin, enhanced apomorphine-induced yawning in rats
Objective: Curcumin is a major constituent of turmeric and influences many functions of the brain. In the present study, we investigated the effect of curcumin on yawning induced by apomorphine in rats. Materials and Methods: Curcumin administered orallyfor 10 consecutive days. Yawning was induced by subcutaneous (s.c.) injection of apomorphine (a dopamine receptor agonist) and the number of ya...
متن کاملSnout contact fixation, climbing and gnawing during apomorphine stereotypy in rats from two substrains.
Apomorphine, at doses greater than or equal to 10 mg/kg (intraperitoneally), produced two patterns of stereotypy. In rats from one supplier it induced predominantly gnawing while in those from another predominantly climbing, suggesting that the response to the drug is influenced by genetic and/or experimental factors. At lower doses, apomorphine induced climbing in both groups (ED50 = 1.4 mg/kg...
متن کاملA reexamination of apomorphine induced stereotypy in the rat in light of self administration experiments.
1. Apomorphine is known to both elicit stereotypy and to support behavioral self administration. The present report examined a possible contribution of stereotypy to self administration. 2. Non-contingent intraperitoneal injection of apomorphine in adult male Sprague-Dawley rats immediately prior to their placement in an experimental chamber significantly elevated barpressing above operant rate...
متن کاملAntagonism of apomorphine-induced cage climbing behaviour and methamphetamine stereotypy by fenfluramine in mice.
Pretreatment with fenfluramine (5 and 10 mg/kg, ip) in doses which induced head twitches was found to antagonize apomorphine-induced cage climbing behaviour and methamphetamine stereotypy in mice. Since fenfluramine (5 and 10 mg/kg) did not induce catalepsy it indicates that fenfluramine lacks postsynaptic striatal and mesolimbic dopamine receptor blocking activity and it is possible that the f...
متن کاملTurmeric active substance, curcumin, enhanced apomorphine-induced yawning in rats
OBJECTIVE Curcumin is a major constituent of turmeric and influences many functions of the brain. In the present study, we investigated the effect of curcumin on yawning induced by apomorphine in rats. MATERIALS AND METHODS Curcumin administered orally for 10 consecutive days. Yawning was induced by subcutaneous (s.c.) injection of apomorphine (a dopamine receptor agonist) and the number of y...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1982
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)54247-0